Finding the best lion’s mane mushroom supplement brand is a significant goal for most consumers because many products leave you craving more.
Most supplements don’t offer the potent effects and easy consumption methods we look for, so we hop from one product to the next. Our goal is to help you finally settle on the best Lion’s mane mushroom supplement.
This guide looks at 11 of the best high-quality Lion’s mane supplements on the market. Let’s dive right in.
At a glance:
- 11 Best Lion’s Mane Mushroom Supplements in 2025
- Frequently Asked Questions
- Ready for More Clarity, Energy, and Drive?
Best Overall — Goomz Mushroom Gummies
While Lion’s mane is a necessary ingredient in the best quality mushroom supplements, we believe Goomz offers some of the best effects you can actually feel.
Why is this?
It’s because we include a proprietary and highly concentrated formula that is tasty and incredibly potent. The Goomz mushroom blend contains some of the best medicinal mushrooms on the market today. Names you’ll likely know and recognize include:
- Reishi
- Chaga
- Lion’s mane
- Cordyceps
- Turkey tail
- Shiitake
- Maitake
Best of all, we use complementary ingredients like Blue lotus for a blissful mood enhancement, Kava root for relaxation, and Kanna to help ease that pesky anxiety. This medicinal blend can do much more for you than even the best organic Lion’s mane mushroom supplement.
We recommend you start with 1 or 2 Goomz gummies, see how you feel for 30 minutes or so, and you can increase your dose from there.
So, what are mushroom lion's mane gummies? Compared to capsules, powder, or pills, they are a much easier and more effective dosing method that comes in various vegan and gluten-free flavors like berry, watermelon, and more!
VitaRaw Organic Lion’s Mane
VitaRaw's organic Lion's mane mushroom capsules pack a powerful 2400 mg punch of this nootropic superfood.
Sourced from nutrient-dense fruiting bodies rather than less potent mycelium, each serving delivers a high concentration of memory and cognition-boosting beta-glucans. VitaRaw only uses a hot water extraction method to retain the mushroom's full spectrum of brain-nourishing terpenes and other compounds.
Many competitors use a dual alcohol/water process that eradicates some of the mushroom's precious nutrients.
With a solid 20 to 40% beta-glucan ratio and added black pepper to amplify absorption, just 4 of these vegan-friendly capsules per day is enough to support neuron growth, sharpen focus, boost energy levels, and maintain clarity of thought.
VitaRaw is also committed to purity and potency, rigorously testing every batch rather than sporadically spot-checking. If you want a mushroom supplement that genuinely lives up to the mushroom's brain-boosting hype, VitaRaw Lion's Mane checks all the boxes.
Shop VitaRaw Organic Lion’s Mane here
New Chapter Lion’s Mane Blend
New Chapter takes a full-spectrum approach with its organic lion’s mane mushroom blend, combining the fruiting bodies and mycelium of lion’s mane with three other beneficial mushroom varieties for maximum brain-boosting effects.
Just two small capsules deliver a hefty 525 mg dose of neuron-regenerating Lion’s mane, along with Reishi, Chaga, and Poria mushrooms, to provide additional cognitive support.
This blend harnesses the unique nootropic compounds inherent to each mushroom species, working synergistically to elevate focus, memory, clarity, and overall brain function.
You can trust New Chapter's commitment to purity and potency as a certified organic, gluten-free, and vegan supplement made exclusively with USA-grown medicinal mushrooms.
While this blend does contain mycelium in addition to the more concentrated fruiting bodies, the diversity of mushrooms and significant 525 mg Lion’s mane dosage make this brand an excellent option for those seeking a daily brain-boosting superfood supplement without breaking the bank.
Shop New Chapter Lion’s Mane Blend here
North Spore Lion’s Mane Tincture
North Spore's dual-extracted mushroom tincture is a top contender for those seeking a highly concentrated, liquid format Lion’s mane supplement.
Sourced from 100% organic lion’s mane mushroom fruiting bodies, this tincture packs more of the mushroom’s neuroprotective and cognition-enhancing compounds than non-extracted varieties.
North Spore uses a month-long cold alcohol soak followed by hot water decoction to fully capture alcohol and water-soluble molecules like hericenones, erinacines, and beta-glucans. These key ingredients synergistically support memory, focus, clarity, and overall nervous system health.
With just 1⁄3 to 1 full dropper per day providing optimal effects, a 2 oz bottle goes a long way. The producer is clearly dedicated to purity and potency, testing every batch for quality before bottling.
North Spore is one of the best brands of Lion’s mane for those who favor a tincture over other consumption methods.
Shop North Spore Lion’s Mane here
Four Sigmatic Think Elixir Box
Four Sigmatic’s Think Elixir delivers a megadose of organic, log-grown Lion’s mane extract (1500 mg) in every serving to sharpen mental clarity and dial in laser focus.
Complimenting the Lion’s mane is Rhodiola, an adaptogenic herb that enhances concentration, while a touch of rose hips and spearmint round out the earthy flavor profile. This combination provides one of the best mushroom supplements for overall brain health.
Simply blend the powder into hot water, coffee, tea, or smoothies for an instant cognitive boost minus the caffeine or sugar crash later.
Four Sigmatic is one of the best lion's mane brands, and also dedicated to purity, rigorously testing every batch for contaminants. If you’re looking for a unique way to get that daily boost, we recommend this top-rated Lion’s mane mushroom supplement.
Shop Four Sigmatic Think Elixir here
Horbaach Lion's Mane Mushroom Extract
Horbaach Lion’s Mane capsules deliver an ultra-potent equivalent of 4,200 mg of organic mushroom extract per serving for next-level cognitive enhancement. The formula also includes BioPerine black pepper extract to amplify the bioavailability of the mushroom’s neuroprotective compounds.
With each vegetarian capsule packing the equivalent punch of over 4 grams of Lion’s mane fruiting bodies, your focus, memory, and clarity can expect a significant boost.
Shop Horbaach Lion’s Mane here
Gaia Herbs Lion’s Mane
Gaia Herbs takes a clean, quality-first approach with its certified organic Lion’s Mane capsules. Grown outdoors to maturity just as in nature, each 450 mg vegan capsule packs the potency punch of a hefty 2.5 grams of mushroom fruiting bodies.
No fillers or mycelium dilute potency. With Lion’s mane valued in traditional wellness practices for the nervous system and cognitive support, Gaia Herbs’ formula makes it easy to incorporate this beneficial mushroom into your daily routine.
We also like their “Meet Your Herbs” tool that shows you the origin and testing data behind each batch. They offer one of the highest quality lion's mane supplements on the market.
Nuvedo Lion’s Mane Mushroom Extract
Nuvedo uses an innovative ultrasonic extraction method to better preserve the bioactive compounds of Lion’s mane mushrooms. That’s a fancy way of saying that more of the good stuff stays in the supplement, so you get a more potent dose.
Nuvedo sources organic, Indian-grown fruiting bodies before using alcohol and hot water extractions to capitalize fully on Lion’s mane’s neuron-supporting potential.
As a convenient, fast-acting supplement free of fillers or additives, a single dropper fully amplifies memory, creativity, focus, and clarity while elevating mood. The company is also mentioned in many Lion's mane mushroom supplement reviews and has an excellent reputation, so if trust is a factor for you, Nuvedo checks out. Overall, this is one of the best lion's mane products on the list.
Double Wood Supplements Lion’s Mane
With a generous 120-capsule bottle providing a 2-month supply, Double Wood Lion’s mane extract helps maintain consistent brain and immune support for the long haul.
These USA-sourced mushroom capsules may stimulate nerve growth factor production to aid cognition while elevating mood and focus. Double Wood also subjects every batch of its vegan, filler-free formula to third-party testing for purity assurance. Overall, it's one of the top lion's mane supplements on the list.
Shop Double Wood Supplements here
Real Mushrooms Lion’s Mane
True to its name, Real Mushrooms infuses real, certified-organic Lion’s mane fruiting bodies into its pure mushroom capsules — no mycelium or fillers allowed. Rather than grain-grown mycelium loaded with starch and fiber, Real Mushrooms capsules contain over 30% immune-enhancing beta-glucans in each capsule for verified potency.
Sustainably harvested and processed to retain biomass integrity, the contents of two capsules are enough to supply cognition and nerve-growth-factor-boosting compounds. This reliability makes these some of the best mushroom supplements for focus.
With third-party testing validating that both ingredients and finished capsules meet purity standards, Real Mushrooms Lion’s mane extract stands out from imposters.
Simply put, Real Mushrooms delivers when 100% real mushroom power is the goal.
This is one of the strongest lion's mane supplements on our list.
Host Defense Capsules
Host Defense packs the cognitive-enhancing power of organic Lion’s mane into convenient one-a-day capsules.
The company’s formula features mycelium biomass cultivated on natural brown rice, then freeze-dried to retain vital compounds like nerve growth factors, which support memory, focus, and clarity. Two capsules deliver an ample 500 mg dose of this brain-boosting fungus.
While these capsules do contain mycelium, they still have a strong and potent formula and are one of the best Lion’s mane mushroom supplement brands in our book.
FAQs
What are the different forms and types of Lion’s mane mushroom supplements?
Lion's mane comes in various forms, including capsules, powders, gummies, liquid tinctures, and loose mushroom pieces. Each form factor has pros and cons depending on your preferences. For example, capsules provide convenient, standardized doses, but tinctures may be absorbed faster. And with gummies, you can get faster absorption without having to swallow an ill-flavored liquid. Overall, it's a very subjective choice based on personal preferences.
What should you look for when buying a lion’s mane supplement?
What you should look for in a lion’s mane supplement is the following:
- Is it a 1:1 or 8:1 extract lion’s mane extract?
- What are the ingredients? Are they high quality? Do they contain fillers or additives? Also, are they third-party tested for purity and potency?
- Are there active compounds like beta-glucans?
- What is the lion’s mane supplement form? Is it gummies, powder, capsules, tincture, or another form?
- Does the brand have an established presence online? Are there a lot of reviews? Are the reviews positive or negative?
- And so on. These are just a few of the key factors you should consider.
What is the best Lion’s mane mushroom supplement?
There's no definitive "best" Lion's mane supplement overall. The highest quality supplements use actual mushroom fruiting bodies rather than mycelium. We'd ensure any brand shows third-party testing for purity and potency. Beyond that, find one with the form, dose, and price that fits your needs.
How often can you take Lion’s mane mushroom supplements?
You can take lion’s mane mushroom gummies for focus daily as long as you follow the serving instructions. Start with the manufacturer’s recommendations and then adjust based on how your body reacts. Some people can take more, while others may want to consume less.
What is the best time of day to take Lion’s mane mushroom supplements?
In our experience, taking the best Lion’s mane mushroom supplement in the morning is ideal for a nice boost. You can also take it in the afternoon to avoid that midday lull.
How long does it take for Lion’s mane mushroom supplements to work?
Patience pays off here! Lion's mane and other mushroom supplements build compounding benefits over time. Give them at least four to six weeks before expecting significant mental clarity or memory improvements.
Are Lion’s mane mushroom supplements safe?
When used as directed, Lion's mane mushroom gummies are likely safe, but it depends on the person, and there are always pros and cons when taking lion's mane (or most other supplements). Some people report temporary digestive upset. As with any new supplement, consult your doctor about pre-existing conditions or medications.
What are the side effects of Lion’s mane mushroom supplements?
Potential side effects could include mild stomach pain, nausea, diarrhea, skin reactions, or more, depending on the individual. Start slowly and stop using if you have an adverse reaction. For more information on the potential side effects of lion's mane supplements, see this article.
Ready for More Clarity, Energy, and Drive?
Finding the best Lion’s mane mushroom supplement shouldn’t have to be complicated. Many functional mushroom supplements are available that can relieve your stress, enhance your mood, and increase your mental clarity.
While we’ve reviewed 11 great options in this guide, our Goomz gummies stand above the competition with a highly concentrated blend of mushrooms and other ingredients that produce effects you can feel in a form factor that’s delicious and easy to take.
You’ll know when you’ve taken a Goomz gummy, and that’s why most people choose the delicious flavors available from the best brand of Lion’s mane supplement.